The invention discloses a method for a preparing guanidine compound, belonging to the field of organic synthesis.
本发明公开了一种胍类化合物的制备方法,属于有机合成领域。
The chiral guanidine—compound(6)was synthesized from the methyl(R)-phenylglycinate hydrochloride as material and the reaction conditions were investigated.
本文以(R)- 苯基甘氨酸甲酯盐为原料合成了手性胍— 化合物(6),并对合成反应条件进行了探索和优化。
The active hydrogen in the compound (6) might take negative effect in some reactions and was substituted by a methyl to get compound (7) which was a new chiral guanidine.
化合物(6)上与氮相连的活泼氢原子,可能对某些反应有不利影响,故用碘甲烷对其进行甲基取代,得到了新的手性胍—化合物(7),并做了表征。
应用推荐